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CDC releases report on synthetic opioid 100 times more potent than fentanyl

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The Centers for Disease Control and Prevention (CDC) is warning about carfentanil, a synthetic opioid that is approximately 10,000 times more potent than morphine and 100 times more potent than fentanyl. The CDC says it has re-emerged in the U.S. drug supply.

Carfentanil was originally designed to tranquilize large mammals like elephants and bears. However, it is now contributing to deaths across the United States.

The potent opioid was detected in over 513 overdose deaths from January 2021 to June 2024, according to the CDC.

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While the overall number remains low, the CDC reports that carfentanil-related deaths increased by 503.4% from June to December 2023. Deaths then rose another 36% in the first half of 2024.

The CDC says there was a total increase of 720.7% in carfentanil deaths from the first half of 2023 to the first half of 2024.

States most affected by carfentanil deaths

The states hardest hit by carfentanil-related deaths were Florida and West Virginia, each reporting more than 20 deaths in 2023.

Illinois, Indiana, Kentucky, Maryland, Michigan, New York and Ohio each reported between 10 and 19 carfentanil deaths during the same period.

In its report, the CDC notes that while the number of deaths attributed to illegally manufactured fentanyl began to decline across the U.S. in late 2023, the overall number of overdose deaths remains high.

The CDC states, “Despite declines, recent sharp increases in overdose deaths with carfentanil detected, although rare, highlight the ever-changing illegal drug supply and threaten progress in reducing overdose deaths.”

Carfentanil’s forms and exposure risks

According to a bulletin published by the Drug Enforcement Administration (DEA), carfentanil can come in several forms. Those forms include powder, blotter paper, tablets, patches and sprays. The skin can absorb some of these forms. People can also accidentally inhale it.

The DEA warns about the potential risks of exposure. Symptoms of carfentanil exposure typically occur within minutes. They may include respiratory depression or arrest, drowsiness, disorientation, sedation, pinpoint pupils and clammy skin.

If you suspect a carfentanil exposure in someone, the DEA advises seeking immediate medical attention. Call EMS and prepare to administer naloxone, an antidote for opioid overdose.

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[Lauren]

A WARNING FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION ON CARFENTANIL, A SYNTHETIC OPIOID APPROXIMATELY 10,000 TIMES MORE POTENT THAN MORPHINE AND 100 TIMES MORE POTENT THAN FENTANYL, HAS RE-EMERGED IN THE US DRUG SUPPLY.

CARFENTANIL WAS DESIGNED TO TRANQUILIZE LARGE MAMMALS LIKE ELEPHANTS AND BEARS AND IT’S NOW KILLING AMERICANS.

THE POTENT OPIOID WAS DETECTED IN MORE THAN 500 (513) OVERDOSE DEATHS FROM JANUARY 2021–JUNE 2024, THE CDC REPORTS.

AND EVEN THOUGH THE NUMBER IS LOW – THE AGENCY SAYS CARFENTANIL DEATHS INCREASED BY MORE THAN 500% (503.4%)  IN FROM JUNE TO DECEMBER 2023.

CARFENTANIL DEATHS THEN INCREASED ANOTHER 36% DURING THE FIRST SIX MONTHS OF THIS YEAR.

THE CDC SAYS THERE WAS A TOTAL INCREASE OF 720.7% FROM THE FIRST HALF OF 2023 TO THE FIRST HALF OF 2024.

THE STATES HIT THE HARDEST BY CARFENTANIL DEATHS WERE FLORIDA AND WEST VIRGINIA EACH REPORTED MORE THAN 20 DEATHS IN 2023.

ILLINOIS, INDIANA, KENTUCKY, MARYLAND, MICHIGAN, NEW YORK, AND OHIO ALL REPORTED BETWEEN 10 AND 19 CARFENTANIL DEATHS.

IN ITS REPORT, THE CDC SAYS ALTHOUGH THE NUMBER OF DEATHS ATTRIBUTED TO THE USE OF ILLEGALLY MANUFACTURED FENTANYLS BEGAN TO DECLINE ACROSS THE US IN LATE 2023, THE NUMBER OF OVERDOSE DEATHS REMAINS HIGH.

THE AGENCY SAYS “DESPITE DECLINES, RECENT SHARP INCREASES IN OVERDOSE DEATHS WITH CARFENTANIL DETECTED, ALTHOUGH RARE, HIGHLIGHT THE EVER-CHANGING ILLEGAL DRUG SUPPLY AND THREATEN PROGRESS IN REDUCING OVERDOSE DEATHS.”

ACCORDING TO A BULLETIN PUBLISHED BY THE DRUG ENFORCEMENT ADMINISTRATION, CARFENTANIL CAN COME IN SEVERAL FORMS, INCLUDING POWDER, BLOTTER PAPER, TABLETS, PATCH, AND SPRAY. SOME FORMS CAN BE ABSORBED THROUGH THE SKIN OR ACCIDENTALLY INHALED.

THE DEA SAYS TO BE AWARE OF EXPOSURE – SYMPTOMS USUALLY OCCUR WITHIN MINUTES AND INCLUDE RESPIRATORY DEPRESSION OR ARREST, DROWSINESS, DISORIENTATION, SEDATION, PINPOINT PUPILS, AND CLAMMY SKIN.

IF YOU SUSPECT SOMEONE HAS BEEN EXPOSED, THE DEA SAYS TO SEEK IMMEDIATE MEDICAL ATTENTION AND CALL EMS IMMEDIATELY AND BE READY TO ADMINISTER NALOXONE, AN ANTIDOTE FOR OPIOID OVERDOSE.